(1) Enlargement of the spleen.

(2) n an abnormal increase in the size of the spleen; often associated with hemolytic anemia, mononucleosis, leukemia, portal hypertension, or malaria (Jonas: Mosby's Dictionary of Complementary and Alternative Medicine. © 2005, Elsevier.)

(3) Enlargement of the spleen. Is largely without clinical signs but it may be palpated during an examination through the abdominal wall in dogs and cats, rectally in horses and not at all in ruminants. The enlargements may be caused by abscess or neoplasm or there may be a diffuse enlargement caused by accumulation of hemolyzed red cells.

Usually the result of trauma or neoplasia.

Banti's disease; splenomegaly secondary to portal hypertension.

That associated with any disorder causing increased erythrocyte degradation.

Splenomegaly with deposit of iron and calcium.

Usually caused by congestion or infiltration of the splenic tissue.